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Serum Uric Acid Predicts Antihypertensive Medication Adherence in Nigeria: A Hospital Based Study

O A Adewuya1, E A Ajayi2, A O Adetiloye3

  • 1Cardiology Unit, Department of Internal Medicine, Ekiti State University Teaching Hospital (EKSUTH) Ado Ekiti, Nigeria.

West African Journal of Medicine
|June 2, 2020
PubMed

Insights

In Nigerian hypertensive patients, low medication adherence is common. Elevated serum uric acid (SUA) levels correlate with poor adherence, suggesting SUA can predict medication compliance.

Area of Science:

  • Cardiology
  • Clinical Pharmacology
  • Biochemistry

Background:

  • Hypertension significantly increases cardiovascular risks.
  • Medication adherence in Nigerian hypertensive patients remains a challenge.
  • Serum markers for predicting adherence require further investigation.

Purpose of the Study:

  • To assess antihypertensive medication adherence levels.
  • To investigate the correlation between serum uric acid (SUA) levels and adherence.
  • To identify predictors of adherence among Nigerian patients.

Main Methods:

  • Recruited 271 hypertensive patients from a cardiology clinic.
  • Measured serum uric acid (SUA) levels and used the MMAS-8 for adherence assessment.
  • Analyzed correlations between SUA and adherence, with linear regression for predictors.

Main Results:

  • Nearly half (48.3%) of patients exhibited low adherence.
  • Elevated SUA levels showed a moderate, significant correlation with non-adherence (r=0.396, p<0.001).
  • SUA levels were identified as a predictor of antihypertensive medication adherence.

Conclusions:

  • Antihypertensive medication adherence was suboptimal in the study population.
  • Elevated SUA levels are linked to lower adherence, influenced by confounding variables.
  • Serum uric acid (SUA) can serve as a potential marker for antihypertensive medication adherence.
Abstract

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