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Immunogenicity of Protein Therapeutics: A Lymph Node Perspective
Kristy Fu1, Kylie March1, Aikaterini Alexaki2
1Tissue Analysis Core, Immunology Laboratory, Vaccine Research Center, NIAID, National Institutes of Health (NIH), Bethesda, MD, United States.
Frontiers in Immunology
|June 2, 2020
Summary
Protein therapeutics face immunogenicity challenges due to antibody development. Understanding adaptive immunity cell roles in antibody responses can reduce this, improving therapeutic efficacy.
Area of Science:
- Molecular biology
- Protein engineering
- Immunology
Background:
- Advancements in protein therapeutics allow for complex *in vivo* administration.
- Therapeutic immunogenicity, leading to antibody development, limits their clinical use.
- Antibody responses are critical for pathogen defense and occur in secondary lymphoid organs.
Purpose of the Study:
- To explore the cellular and molecular mechanisms behind antibody responses to protein therapeutics.
- To identify strategies for reducing therapeutic immunogenicity and enhancing efficacy.
Main Methods:
- Focus on the role of adaptive immunity cells, specifically follicular helper CD4 T cells and germinal center B cells.
- Investigating the anatomical sites of antibody response generation, including B cell follicles and germinal centers.
Main Results:
- Highlighting the importance of coordinated adaptive immunity cell function in generating antibody responses.
- Identifying key cellular players and anatomical locations involved in immune reactions to therapeutics.
Conclusions:
- Understanding immune mechanisms against therapeutics is key to overcoming immunogenicity.
- Novel strategies can be developed to improve the safety and effectiveness of protein therapeutics.
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