Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Dec 20, 2025

Three-dimensional Optical-resolution Photoacoustic Microscopy

Three-dimensional Optical-resolution Photoacoustic Microscopy

Published on: May 3, 2011

Hermetically Packaged Microsensor for Quality Factor-Enhanced Photoacoustic Biosensing.

Imran Latif¹, Masaya Toda¹, Takahito Ono^1,2

¹Department of Mechanical Systems Engineering, Tohoku University, Japan.

|June 2, 2020

Summary

This study introduces a novel microscale resonator for photoacoustic biosensing, achieving high signal-to-noise ratios. The technology enables sensitive detection of trace glucose in synthetic tissues, advancing micro/nano biosensing applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effect of Channel Height on CO<sub>2</sub>-to-CH<sub>4</sub> Reduction in Microchannel Electrocatalysis.

Micromachines·2026

Same author

Editorial for the Special Issue on MEMS/NEMS Devices and Applications, 3rd Edition.

Micromachines·2026

Same author

High sensitivity chemiresistive biosensor prepared via enzyme-catalyzed redox and nanoparticle conduction network.

Microsystems & nanoengineering·2026

Same author

Measuring the Operating Condition of Induction Motor Using High-Sensitivity Magnetic Sensor.

Sensors (Basel, Switzerland)·2025

Same author

Ultra-High Sensitivity, Wide-Range Thermometry Based on High-Quality Microscale Diamond Resonators.

Advanced materials (Deerfield Beach, Fla.)·2025

Same author

Investigation towards nanomechanical sensor array for real-time detection of complex gases.

Microsystems & nanoengineering·2025

Area of Science:

Biomedical Engineering
Analytical Chemistry
Materials Science

Background:

Photoacoustics (PA) is a valuable non-invasive tool in biomedicine.
Existing PA systems face limitations in signal-to-noise ratio and stability for micro/nano biosensing.
Microfabrication offers enhanced performance and miniaturization potential for PA detection.

Purpose of the Study:

To develop a novel microscale resonator for photoacoustic biosensing.
To demonstrate high signal-to-noise ratios and steady operation in a miniaturized PA system.
To explore the application of this technology for detecting trace analytes.

Main Methods:

Implementation of a vacuum-packaged microscale resonator.
Utilizing microfabrication technology for enhanced transducer performance.

Keywords:

Biosensing Micromechanical resonator Photoacoustics Quality factor Vacuum-packaged

More Related Videos

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Photoacoustic Cystography

Photoacoustic Cystography

Published on: June 11, 2013

Related Experiment Videos

Last Updated: Dec 20, 2025

Three-dimensional Optical-resolution Photoacoustic Microscopy

Three-dimensional Optical-resolution Photoacoustic Microscopy

Published on: May 3, 2011

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Photoacoustic Cystography

Photoacoustic Cystography

Published on: June 11, 2013

Detecting photoacoustic signals from trace glucose variations in synthetic tissues.

Main Results:

Demonstrated steady operation of the microscale resonator in photoacoustic biosensing.
Successfully detected minuscule photoacoustic signals from trace glucose amounts.
Achieved high signal-to-noise ratios in a miniaturized system.

Conclusions:

The vacuum-packaged microscale resonator represents a significant advancement in photoacoustic biosensing.
This novel approach shows potential for micro-biosensing modules and analysis of various analytes.
The technology offers a pathway to practical micro/nano biosensing applications with enhanced performance.