Related Experiment Video

Updated: Dec 20, 2025

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

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Sevoflurane inhibits growth factor-induced angiogenesis through suppressing Rac1/paxillin/FAK and Ras/Akt/mTOR

Xuesong Wang1, Yao Yao1, Jin Gao1

  • 1Department of Anesthesiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts & Science, Xiangyang, Hubei Province 441021, PR China.

Future Oncology (London, England)
|June 2, 2020
PubMed

Insights

Sevoflurane exhibits anti-angiogenic properties, inhibiting endothelial cell function and capillary formation at low doses. It also impacts tumor cell growth and metastasis pathways, suggesting potential in cancer therapy.

Area of Science:

  • Anesthesiology
  • Oncology
  • Cell Biology

Background:

  • Anesthetics like sevoflurane may influence cellular processes beyond anesthesia.
  • Understanding these effects is crucial for assessing their impact on diseases like cancer.

Purpose of the Study:

  • To investigate the direct impact of sevoflurane on angiogenesis.
  • To evaluate sevoflurane's effects on various tumor cell lines.
  • To elucidate the underlying molecular mechanisms.

Main Methods:

  • Sevoflurane's anti-angiogenic activity was assessed using angiogenesis and biochemical assays.
  • Endothelial cell migration, adhesion, and apoptosis assays were performed.
  • Tumor cell growth and migration were measured.
  • Ras and Rac1 signaling pathway activation was analyzed.

Main Results:

  • Low-dose sevoflurane inhibited capillary network formation and endothelial cell function (migration, adhesion, growth), inducing apoptosis.
  • High-dose sevoflurane inhibited tumor cell growth and migration, indicating differential effects.
  • Sevoflurane suppressed growth factor-induced Ras and Rac1 activation and downstream signaling.

Conclusions:

  • Sevoflurane demonstrates significant anti-angiogenic effects.
  • Preclinical evidence suggests sevoflurane may impede cancer growth and metastasis through specific molecular pathways.
Keywords:
Rac1Rasangiogenesissevofluranevolatile anesthetics

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