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Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
Published on: January 14, 2014
The effect of naftidrofuryl on PGF2 alpha, U 46.619, 5-HT and thromboxane A2 (TXA2) induced vasoconstriction
1Neurochirurgische Klinik, Universität Göttingen, FRG.
Abstract:
This study was designed to investigate the effects of Naftidrofuryl on platelet function and vessel tone and additionally platelet vessel wall interactions. It is shown that Naftidrofuryl displays a spasmolytic activity against a variety of different vasoconstrictors, including 5-HT, PGF2 alpha, U 46.619 and KC1 and inhibits platelet secretion. These effects are observed at concentrations of the compound equal to or higher than 1 mumol/l and might contribute to the clinical efficacy of the drug.
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