Related Experiment Video
Updated: Dec 20, 2025

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
Published on: June 2, 2023
Products of Lipid Peroxidation as a Factor in the Toxic Effect of Silver Nanoparticles
Patrycja Paciorek1, Mariusz Żuberek1, Agnieszka Grzelak1
1Department of molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.
Abstract:
In our previous study we have shown that nanoparticles have different effects depending on the energy metabolism of the cell, which is an important factor in the context of oncology and diabetes. Here we assess the influence of AgNPs on cellular lipid components in varying glucose concentrations. To assess the effect of silver nanoparticles on cell lipids, we measured cell viability, the fluidity of the cell membranes, the content of amino groups in proteins, the level of lipid peroxidation products, the concentration of 4-hydroxynonenal (4-HNE), and the concentration of lipid peroxides. The obtained results show differences in the formation of lipid peroxidation products in cells exposed to oxidative stress induced by nanoparticles. In addition, we have shown that the metabolic state of the cell is a factor significantly affecting this process.
More Related Videos
Related Concept Videos
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Formation of Complex Ions
Peroxisomes
Radical Autoxidation

