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Chip-based Three-dimensional Cell Culture in Perfused Micro-bioreactors
Published on: May 21, 2008
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Three-dimensional cell culture based on microfluidic techniques to mimic living tissues
Yuya Morimoto1, Shoji Takeuchi
1Center for International Research on Micronano Mechatronics (CIRMM), Institute of Industrial Science (IIS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
Biomaterials Science
|June 3, 2020
Summary
Microfluidic techniques enable reproducible fabrication of uniform cellular spheroids and cell-laden hydrogels. These structures serve as building blocks for advanced tissue engineering, facilitating disease treatment and human implantation applications.
Area of Science:
- Biotechnology
- Materials Science
- Regenerative Medicine
Background:
- Cellular spheroids and cell-laden hydrogels are crucial for tissue engineering.
- Current fabrication methods can lack control over size and uniformity.
Purpose of the Study:
- To review microfluidic fabrication methods for cellular spheroids and cell-laden hydrogels.
- To highlight their applications in tissue engineering.
Main Methods:
- Microfluidic devices are utilized for the controlled formation of cellular spheroids.
- Microfluidic systems facilitate the encapsulation of cells within hydrogels with precise design.
Main Results:
- Microfluidic fabrication yields reproducible and size-uniform cellular spheroids and hydrogels.
- These uniform building blocks enable the construction of tissues with controlled shapes and sizes.
Conclusions:
- Microfluidic techniques offer powerful tools for creating engineered tissues.
- These advancements hold significant potential for human implantation and disease treatment.
