Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

High-Performance Liquid Chromatography: Types of Detectors

High-Performance Liquid Chromatography: Types of Detectors

The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte properties and...

Gas Chromatography: Types of Detectors-II

Gas Chromatography: Types of Detectors-II

In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026

Same author

Insect Olfactory Receptor-Expressing Sensor Cells for Colorectal Cancer Diagnosis Using Urine Samples.

Cancer medicine·2026

Same author

Living sensor display implanted on skin for long-term biomarker monitoring.

Nature communications·2026

Same author

Integrative Real-Time NMR and X-ray Crystallography Reveal Prostaglandin D<sub>2</sub> Metabolism.

Analytical chemistry·2025

Same author

Intercalant Aggregation Promotes Nanoscopic Depletion in Droplet Interface Bilayers.

The journal of physical chemistry. B·2025

Same author

Shape-Encoded Hydrogel Sensor Particles Enable Multiplex Odorant Detection Through Deep-learning Classification.

Small (Weinheim an der Bergstrasse, Germany)·2025

Same journal

Modulating Electronic Structure via Bimetallic D<i>-</i>Band Engineering toward an Ultrasensitive Sensor Platform for Caffeic Acid in Food.

ACS sensors·2026

Same journal

Indiscriminate <i>T</i><i>rans</i>-Cleavage Activity of CRISPR/SuCas12a2 Enables Sensitive Detection of SARS-CoV-2.

ACS sensors·2026

Same journal

Spin-State Engineering in 2D Metal-Organic Frameworks for Ultrasensitive Room-Temperature Ammonia Sensing.

ACS sensors·2026

Same journal

A Wearable Microneedle-Based Electrochemical Aptamer Sensor: Enabling Real-Time Dynamic NT-proBNP Monitoring for Enhanced Heart Failure Management.

ACS sensors·2026

Same journal

Double-Strand Gated Biosensor for Ultrasensitive T4 PNK Detection via λ-Exonuclease-Driven Background Suppression and Dimer G-Triplex Signal Amplification.

ACS sensors·2026

Same journal

Junction-Amplified Porous SnO<sub>2</sub>-Co<sub>3</sub>O<sub>4</sub> Nanospheres for ppb-Level Low-Temperature Acetone Detection and Wearable-Integrated Breath Monitoring.

ACS sensors·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics

Published on: December 8, 2023

Cell-Based Multisensor Array for Vapor-Phase Detection of Cancer-Related Compounds in Human Urine.

Hisatoshi Mimura¹, Toshihisa Osaki¹, Haruka Oda²

¹Artificial Cell Membrane Systems Group, Kanagawa Institute of Industrial Science and Technology, 3-2-1 Sakado, Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan.

|June 9, 2026

Summary

This summary is machine-generated.

This study introduces a novel cell-based sensor platform for detecting volatile biomarker candidates in complex biological samples. The innovative microwell design enhances sensitivity and reduces variability for noninvasive disease screening.

Keywords:

biohybrid robotics biohybrid sensors cell-based sensors olfactory receptors urine analysis volatile biomarkers

More Related Videos

Exploring the Application of Surface-enhanced Raman Scattering-based Biosensing of Individual sEVs in Disease Diagnosis and Therapeutics

Exploring the Application of Surface-enhanced Raman Scattering-based Biosensing of Individual sEVs in Disease Diagnosis and Therapeutics

Published on: March 13, 2026

Related Experiment Videos

Last Updated: Jun 11, 2026

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics

Published on: December 8, 2023

Exploring the Application of Surface-enhanced Raman Scattering-based Biosensing of Individual sEVs in Disease Diagnosis and Therapeutics

Exploring the Application of Surface-enhanced Raman Scattering-based Biosensing of Individual sEVs in Disease Diagnosis and Therapeutics

Published on: March 13, 2026

Area of Science:

Sensor science
Biomolecular detection
Cell-based biosensors

Background:

Detecting volatile biomarkers in biological samples is crucial for noninvasive disease screening.
Existing biohybrid sensors face challenges with weak fluorescence signals and cellular response variability.

Purpose of the Study:

To develop an advanced cell-based multisensor platform for enhanced detection of volatile biomarker candidates.
To improve sensitivity and reduce signal variability in biosensing applications using a novel microstructural design.

Main Methods:

Insect olfactory receptor-expressing cells were encapsulated in hydrogel and immobilized within slit-integrated microwells.
This design facilitated dense cell loading, uniform molecule exposure, and reproducible multisensor array fabrication.
Hexane extraction combined with vapor-phase exposure was used for sample analysis.

Main Results:

The platform demonstrated enhanced fluorescence response sensitivity and reduced signal variability.
Selective and simultaneous detection of cancer-related volatile molecules (acetophenone, phenol, 6-methyl-5-hepten-2-one) was achieved.
Reliable detection of acetophenone in human urine samples at micromolar concentrations was confirmed.

Conclusions:

The developed cell-based multisensor platform offers a compact, reproducible, and scalable strategy for volatile molecule detection.
This technology holds promise for noninvasive disease screening by analyzing complex biological samples.
The microwell architecture significantly improves the performance of biohybrid sensors.