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Viscoelastic hydrogels from poly(vinyl alcohol)-Fe(iii) complex.

Narahari Mahanta¹, Yiwei Teow, Suresh Valiyaveettil

¹Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore. chmsv@nus.edu.sg.

Biomaterials Science

|June 3, 2020

Summary

This study developed a stable, porous hydrogel from polyvinyl alcohol (PVA) crosslinked with Fe3+ ions. The resulting material exhibits excellent viscoelasticity and biocompatibility, making it suitable for biomedical applications.

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Published on: October 26, 2016

Area of Science:

Materials Science
Biomaterials Engineering
Polymer Chemistry

Background:

Hydrogels are hydrophilic polymer scaffolds with water channels.
Polyvinyl alcohol (PVA) is a versatile polymer for biomaterial development.

Purpose of the Study:

To fabricate a highly viscoelastic hydrogel using PVA.
To investigate the properties and potential biomedical applications of the synthesized hydrogel.

Main Methods:

Polyvinyl alcohol (PVA) was crosslinked with Fe3+ ions under basic conditions.
Swelling ratio, compressive modulus, and dynamic viscoelasticity were evaluated.
Creep studies and thermal analysis (glass transition, melting point, enthalpy) were performed.
Cytocompatibility was assessed using human lung fibroblasts (IMR-90).

Main Results:

A stable, porous hydrogel with high viscoelasticity was successfully fabricated.
Swelling ratio correlated with the metal-coordinated crosslinked network structure.
The hydrogel demonstrated good thermal stability up to 45 °C.
Elastic recovery improved with increased crosslinking.
No significant toxic effects or cell attachment were observed on the hydrogel surface after 5 days.

Conclusions:

The PVA-based hydrogel exhibits promising viscoelastic, mechanical, and thermal properties.
The hydrogel is cytocompatible, indicating potential for biomedical use.
These hydrogels are suitable for applications requiring stable, biocompatible biomaterials.