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Prevalence of Chronic Hepatitis B Virus Infection in the United States

Joseph K Lim1, Mindie H Nguyen2, W Ray Kim2

  • 1Yale Viral Hepatitis Program, Section of Digestive Diseases/Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA.

The American Journal of Gastroenterology
|June 3, 2020
PubMed

Insights

An estimated 1.59 million people in the US have chronic hepatitis B virus (HBV) infection. This updated prevalence estimate is crucial for informing hepatitis B elimination strategies and prevention efforts.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health Epidemiology

Background:

  • Chronic hepatitis B virus (HBV) infection is a significant global health concern, leading to severe liver conditions like cirrhosis and liver cancer.
  • Despite available interventions, the prevalence of chronic HBV remains high in the United States, necessitating updated epidemiological data.

Purpose of the Study:

  • To conduct an updated literature review and develop a contemporary prevalence range estimate for chronic HBV infection in the US.
  • To inform the World Health Organization (WHO) and US Department of Health and Human Services (DHHS) hepatitis elimination plans with current epidemiological insights.

Main Methods:

  • A panel of leading US hepatologists performed a comprehensive review of peer-reviewed literature on HBV prevalence.
  • Findings were discussed and synthesized during a live HBV epidemiology workshop in May 2019.

Main Results:

  • The estimated prevalence of chronic HBV infection in the US is 1.59 million persons.
  • The proposed prevalence range for chronic HBV infection in the US is 1.25 to 2.49 million persons.

Conclusions:

  • The updated prevalence estimate provides critical data for national hepatitis B elimination initiatives.
  • Findings support the need for enhanced HBV screening and prevention strategies within the United States.

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