Related Experiment Video
Updated: Dec 20, 2025
11:50
A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
Published on: February 4, 2022
4.4K
Neck Circumference and Cerebral Gray Matter Volume
Chol Shin1, Regina E Y Kim1, Robert J Thomas2,3
1Institute of Human Genomic Study, Korea University College of Medicine, Ansan-si.
Alzheimer Disease and Associated Disorders
|June 3, 2020
Summary
Increased neck circumference (NC) is linked to reduced gray matter brain volume in men with diabetes. This finding suggests neck adiposity may impact brain aging, particularly in diabetic populations.
Area of Science:
- Neuroscience
- Metabolic Health
- Medical Imaging
Background:
- Obesity is associated with brain atrophy and dementia.
- Regional adiposity's link to brain structure remains unclear.
- Neck circumference (NC) is a marker for regional adiposity with metabolic and cardiovascular implications.
Purpose of the Study:
- To investigate the association between neck circumference and cerebral gray matter volume.
- To determine if regional adiposity, measured by NC, relates to brain structure.
Main Methods:
- Cross-sectional study of 2916 participants from the Korean Genome and Epidemiology Study (2011-2014).
- Magnetic resonance imaging (MRI) used to assess cerebral gray matter volume.
- Neck circumference measured as a proxy for regional adiposity.
Main Results:
- In men, higher NC was inversely associated with total and regional gray matter volume (frontal, temporal, occipital lobes).
- This association was stronger in men with diabetes.
- Diabetic men showed a significant reduction in total and frontal gray matter volume with increasing NC.
Conclusions:
- Neck circumference is inversely associated with cerebral gray matter volume in men with diabetes.
- Neck adiposity may play a role in brain aging among diabetic men.
- Further research is warranted on the link between neck anthropometry and brain health in this population.
Related Concept Videos
01:16Spinal Cord: Cross-sectional Anatomy
3.8K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
3.8K
01:11Cerebrum: Anatomical Overview II
4.0K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
4.0K
01:20Anatomy of the Brain: Major Regions
9.2K
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
9.2K
01:26Arteries of the Head and Neck
2.7K
The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
2.7K
01:17Cerebellum: Anatomical Regions
3.7K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
3.7K
01:18Anatomy of the Brain: Ventricles
7.3K
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
7.3K