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Updated: Dec 20, 2025
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and
Javad Seyyedi1, Shahab Alizadeh2
1Department of Medical Surgical Nursing, School of Nursing & Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
Background:
This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin.
Methods:
PubMed, Scopus, and Google scholar were systematically searched to identify related studies published from inception to November 2019 to find eligible studies.
Results:
A total of 29 different studies were included. BS reduced the concentrations of MCP-1 (weighted mean difference (WMD) = - 58.91; 95%CI (confidence interval), - 77.10 to - 40.72; P = ˂ 0.001), ICAM-1 (WMD = - 36.58; 95%CI, - 49.65 to - 23.52; P = ˂ 0.001), and E-selectin (WMD = - 11.22; 95%CI, - 14.43 to - 8.01; P < 0.001), but had no significant effect on VCAM-1.
Conclusion:
Bariatric surgery reduces circulating concentration of MCP-1, ICAM-1, and E-selectin, but not VCAM-1.
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