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Related Experiment Video

Updated: Dec 20, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

[Covid-19 - radiologic and histologic features].

Ann Mari Svensson¹, Tomas Hansen², Sven Nyren³

¹biträdande överläkare, ME radiologi KS Solna, Karolinska universitetssjukhuset.

|June 3, 2020

Summary

This summary is machine-generated.

This study details the lung imaging and biopsy findings of coronavirus disease (COVID-19). It correlates computed tomography (CT) scans with histopathology, revealing progressive changes from ground-glass opacities to diffuse alveolar damage.

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Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

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Published on: December 23, 2020

Area of Science:

Pulmonology
Radiology
Pathology

Background:

Coronavirus disease (COVID-19), caused by SARS-CoV-2, presents with diverse pulmonary manifestations.
Understanding the radiologic and histologic features is crucial for diagnosis and management.

Purpose of the Study:

To describe the current knowledge on radiologic and histologic pulmonary features of COVID-19.
To present lung histology from a fatal COVID-19 case.
To correlate imaging findings with histopathologic changes.

Main Methods:

Review of current literature on COVID-19 pulmonary findings.
Presentation of computed tomography (CT) findings.
Detailed description of lung histology from a fatal case.

Main Results:

Initial CT findings include peripheral, bilateral ground-glass opacities and alveolar edema.
Progression shows peripheral consolidations, organizing pneumonia, and potentially reversible fibrosis.
Severe cases exhibit thickened interlobular septa and crazy paving patterns, correlating with diffuse alveolar damage (DAD).
Histologic DAD features include edema, hyaline membranes, reactive epithelium, inflammation, and fibrosis.

Conclusions:

CT findings evolve with disease severity, reflecting underlying histopathologic changes.
Peripheral and posterior lung involvement is characteristic.
The progression of radiologic findings mirrors the stages of diffuse alveolar damage in severe COVID-19.