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Scabies: A comprehensive review and current perspectives.

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Human scabies, a neglected tropical disease (NTD), is a widespread skin infestation. This review covers its clinical presentation, diagnosis, and management, highlighting the need for new treatments.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Parasitology

Background:

  • Human scabies is a contagious skin infestation caused by the mite Sarcoptes scabiei var. hominis.
  • It is a globally prevalent skin disease affecting all socioeconomic strata.
  • The World Health Organization (WHO) classified scabies as a neglected tropical disease (NTD) in 2009.

Purpose of the Study:

  • To review the diverse clinical presentations of human scabies.
  • To summarize recent advancements in the diagnosis and management of scabies.
  • To discuss the ongoing search for novel therapeutic agents for scabies.

Main Methods:

  • Literature search of peer-reviewed articles, clinical trials, and scientific reviews.
  • Databases searched include MEDLINE and PubMed up to February 2020.
  • Inclusion criteria: English language publications.

Main Results:

  • Scabies presents with varied clinical manifestations.
  • Advances in diagnostic methods and treatment strategies are emerging.
  • Challenges with conventional treatments necessitate the development of new agents.

Conclusions:

  • Effective management of human scabies requires community awareness and updated treatment strategies.
  • Continued research is crucial for developing novel therapies to address treatment resistance and improve patient outcomes.
  • Understanding the varied clinical presentations aids in timely diagnosis and effective management.