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Long Noncoding RNAs Involved in the Endocrine Therapy Resistance of Breast Cancer

Toshihiko Takeiwa1, Kazuhiro Ikeda1, Yuichi Mitobe1

  • 1Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama 350-1241, Japan.

Cancers
|June 4, 2020
PubMed

Insights

Long noncoding RNAs (lncRNAs) are key players in various cancers. This review highlights their role in endocrine therapy resistance in breast cancer, suggesting potential as biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that do not code for proteins.
  • Aberrant lncRNA expression is implicated in the pathogenesis of numerous human cancers.
  • Endocrine therapy resistance is a significant clinical challenge in breast cancer treatment.

Purpose of the Study:

  • To summarize the known functions and mechanisms of lncRNAs involved in endocrine therapy resistance in breast cancer.
  • To explore the potential of lncRNAs as biomarkers for predicting treatment response.
  • To discuss the therapeutic implications of targeting lncRNAs in endocrine-resistant breast cancer.

Main Methods:

  • Literature review of studies investigating lncRNAs in breast cancer and endocrine therapy resistance.
  • Analysis of reported molecular mechanisms underlying lncRNA involvement.
  • Synthesis of findings related to diagnostic and therapeutic potential.

Main Results:

  • Numerous lncRNAs are expressed in human cancers, including breast cancer.
  • Specific lncRNAs have been identified to promote or mediate resistance to endocrine therapies.
  • These lncRNAs operate through diverse molecular pathways.

Conclusions:

  • lncRNAs represent a critical regulatory layer in endocrine therapy resistance in breast cancer.
  • lncRNAs hold significant promise as novel biomarkers for treatment selection and prognosis.
  • Targeting lncRNAs may offer innovative therapeutic strategies to overcome endocrine resistance.
Keywords:
breast cancerendocrine therapyendocrine therapy resistancelong noncoding RNA

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