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Updated: Dec 20, 2025
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
[Clinical features and high resolution CT imaging evolution of coronavirus disease 2019]
1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Insights
This study analyzed 141 coronavirus disease 2019 (COVID-19) patients, finding fever is the most common symptom. High Resolution CT (HRCT) imaging revealed diverse lung abnormalities, aiding in early detection and severity assessment.
Area of Science:
- Radiology
- Infectious Diseases
- Pulmonology
Background:
- Coronavirus disease 2019 (COVID-19) emerged as a global pandemic.
- Understanding the clinical and imaging characteristics is crucial for patient management.
Purpose of the Study:
- To investigate the clinical manifestations and High Resolution CT (HRCT) imaging evolution in 141 COVID-19 patients.
- To correlate HRCT findings with disease severity and nucleic acid test results.
Main Methods:
- Retrospective analysis of 141 COVID-19 patients (January 20 - February 8, 2020).
- Clinical features, laboratory data, and serial chest HRCT findings were analyzed.
- Correlation with viral nucleic acid test results and disease progression.
Main Results:
- Fever (>37.5°C) was present in 98.58% of patients; diarrhea was occasionally observed.
- Abnormal HRCT findings included ground-glass opacity (GGO), consolidation, and bronchovascular bundle thickening.
- Nucleic acid tests were often positive concurrently with or prior to HRCT findings, with noted false negatives.
Conclusions:
- COVID-19 presents diverse clinical and HRCT features, with GGO and bilateral infiltrates being typical.
- HRCT imaging is significant for early lung injury warning, severity assessment, and clinical typing.
- Serial HRCT and nucleic acid testing aid in monitoring disease progression and post-treatment follow-up.
Abstract:
Objective: To investigate the clinical manifestations of the clinical characteristics of 141 patients with coronavirus disease 2019 (COVID-19) and the imaging evolution characteristics of High Resolution CT (HRCT) in the chest. Methods: From January 20, 2020 to February 8, 141 COVID-19 patients in Renmin Hospital of Wuhan University, 77 males and 64 females, with a median age of 49 (9,87) , were retrospectively analyzed. The clinical features, laboratory examination indexes and HRCT evolution findings of 141 COVID-19 patients were analyzed. Results: Laboratory examinations of 141 COVID-19 patients showed a decrease in white blood cell count and lymphocyte ratio. Among the 141 patients with COVID-19, fever (>37.5 ℃) was the most common clinical manifestation in 139 cases (98.58%) , and occasionally non-respiratory symptoms such as diarrhea in 4 cases (2.84%) . 141 patients with COVID-19 had abnormal HRCT. 52 (36.88%) chest HRCT images showed ground-glass opacity (GGO) , mainly under pleural; 23 (16.31%) GGO with focal consolidation; 27 (19.15%) small flaky shadows; 20 cases (14.18%) large flaky consolidation shadows; 48 cases (34.04%) bronchovascular bundle thickening and vascular penetrating signs; 5 cases (3.55%) had air bronchial signs; 7 cases (4.96%) of small nodule shadows; 5 cases (3.55%) of fibrosis, grid shadows or strand shadows.135 cases (95.74%) were positive for the first time nucleic acid test, 6 cases (4.26%) were negative, and 71 cases (50.35%) of common type, 47 cases (33.33%) of severe type and 23 cases (16.31%) of critical type were found during the same period. The average time from onset of each type to the first CT examination was: (2.51±1.32) , (5.02±2.01) , and (5.91±1.76) days; 19 (19/47, 40.43%) of which were severe for the first time CT classification worsened at the second examination and lessened at the third examination. 141 cases (100%) were positive for the second nucleic acid test, and the HRCT results for the same period were 44 cases (31.21%) of common type, 53 cases (37.59%) of severe type, and 44 cases (31.21%) of critical type; the average interval time was (3.32±1.61) , (3.93±1.84) , (4.15±1.57) days;the third nucleic acid test were positive among 113 cases and 28 cases were negative, HRCT results of the same period were 79 cases (56.03%) of common type, 46 cases (32.62%) of severe type, and 16 cases (11.35%) of critical type;the average interval from the first CT examination were: (5.59±1.83) , (7.32±1.37) , (7.55±1.78) days. The differences in CT typing at different time were statistically significant (P<0.05) . Conclusion: The clinical features of COVID-19 and HRCT images are diverse, extensive GGO and infiltrates in both lungs are typical. Viral nucleic acid tests usually occur earlier or at the same time as the CT examination positive, and there are false negatives in nucleic acid tests. In some epidemiological backgrounds, CT imaging manifestations and evolutionary characteristics are of great significance for early warning of lung injury, assessment of disease severity, and assistance in clinical typing and post-treatment follow-up.
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