Comparative study of electrospun crystal-based and composite-based drug nano depots

Area of Science:

• Materials Science
• Nanotechnology
• Pharmaceutical Sciences

Background:

• Complex nanostructures are crucial for developing advanced functional nanomaterials.
• Nano drug depots with core-shell structures are vital for controlled drug delivery systems.

Purpose of the Study:

• To prepare and compare the drug-sustained release performance of two distinct nano drug depots.
• To investigate the influence of drug reservoir state on release kinetics.

Main Methods:

• Modified triaxial electrospinning technique was employed to fabricate nano drug depots.
• Two types of reservoirs were prepared: crystal drug and medicated composite drug.
• Drug-sustained release profiles were analyzed, focusing on initial burst, linear, and tailing off release phases.

Main Results:

• Both depot types exhibited core-shell nanostructures with cellulose acetate shells.
• Composite-based depots showed significantly reduced tailing off drug release (2.2% over 12 h) compared to crystal-based depots (9.3% over 36 h).
• Composite depots exhibited better zero-order controlled release kinetics.

Conclusions:

• The state of the drug within the core reservoir critically influences sustained release performance.
• Modified triaxial electrospinning offers a promising method for producing medicated structural nanomaterials with tailored release profiles.