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Robust dual modality antibacterial action using silver-Prussian blue nanoscale coordination polymer.

Shalini Sharma1, Nayanika Chakraborty1, Diksha Jha2

  • 1Department of Chemistry, University of Delhi, Delhi, 110007, India.

Materials Science & Engineering. C, Materials for Biological Applications
|June 4, 2020
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Summary

Silver-doped Prussian blue nanoscale coordination polymers (SPB NCPs) exhibit dual antibacterial actions: oxidative toxicity and photothermal ablation. These SPB NCPs show enhanced efficacy compared to traditional Prussian blue NCPs, offering a promising low-dosage antibacterial strategy.

Keywords:
Antibacterial actionNanoscale coordination polymer (NCP)Photothermal therapy (PTT)Prussian blue (PB)Reactive oxygen species (ROS)Silver-doped Prussian blue (SPB)

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Area of Science:

  • Nanomaterials Science
  • Biomedical Engineering
  • Chemistry

Background:

  • Prussian blue nanoscale coordination polymers (PB NCPs) are explored for therapeutic applications.
  • Developing novel antibacterial agents with enhanced efficacy is crucial for combating infections.

Purpose of the Study:

  • To synthesize and characterize silver-doped Prussian blue nanoscale coordination polymers (SPB NCPs).
  • To investigate the dual antibacterial mechanisms of SPB NCPs, including oxidative toxicity and photothermal ablation.
  • To compare the therapeutic properties of SPB NCPs with conventional PB NCPs.

Main Methods:

  • Synthesis of SPB NCPs and PB NCPs.
  • Characterization of physical, crystalline, and optical properties.
  • Evaluation of photothermal effect upon red laser light exposure.
  • Assessment of oxidase-like activity and hydrogen peroxide generation.
  • In vitro antibacterial studies to determine toxicity and efficacy.

Main Results:

  • SPB NCPs and PB NCPs exhibit similar physical dimensions, crystalline phase, and optical properties.
  • Both NCPs demonstrate robust photothermal effects.
  • SPB NCPs exhibit oxidase-like activity, generating H2O2, unlike PB NCPs.
  • SPB NCPs show inherent antibacterial toxicity (IC50 ≈ 2.5 μg/ml) attributed to oxidative stress.
  • SPB NCPs combined with light activation show significant synergistic antibacterial effects.

Conclusions:

  • SPB NCPs possess dual antibacterial modalities: inherent oxidative toxicity and light-activated photothermal toxicity.
  • The silver content in SPB NCPs is responsible for the observed oxidase-like activity and enhanced antibacterial efficacy.
  • SPB NCPs represent a promising class of antibacterial agents effective at low dosages due to their combined toxicities.