Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bracket Coding: The Optimal Balance Between Temporal Integration and Segregation in Early Visual Processing.

bioRxiv : the preprint server for biology·2026

Same author

Biodegradable Intra-arterial Devices for Focal Drug Delivery to Targeted Organs.

bioRxiv : the preprint server for biology·2026

Same author

Sensory-to-motor transformations: From serial pipelines to dynamic, distributed processes.

Neuroscience and biobehavioral reviews·2026

Same author

Beta bursts mediate amygdala gating of hippocampal emotional encoding.

bioRxiv : the preprint server for biology·2025

Same author

Cellular and circuit features distinguish mouse dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation.

eLife·2025

Same author

Cellular and circuit features distinguish dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation.

bioRxiv : the preprint server for biology·2024

Same journal

Vestibular function drives gaze stability in locomoting macaques.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same journal

Region- and layer-specific glutamatergic synapse development in the nascent cortical hierarchy.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same journal

Endogenous peptide derived from c-Cbl-associated protein counteracts its inhibitory effect on enteric neural crest cell colonization in Hirschsprung disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same journal

Drowsiness alters the neural dynamics but not the core computations of multisensory integration.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same journal

A Matter of Parameters: Tailored Transcranial Focused Ultrasound Enhances Cortico-Thalamo-Cortical Circuit Resonance.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same journal

Proactive visual and motor prioritization differentially scale with cue reliability.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 19, 2025

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

Functional Localization of an Attenuating Filter within Cortex for a Selective Detection Task in Mice.

Krithiga Aruljothi¹, Krista Marrero², Zhaoran Zhang²

¹Department of Psychology.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|June 4, 2020

Summary

This summary is machine-generated.

Mice learned to detect target whisker stimuli while ignoring distractor stimuli. Neural imaging revealed target responses across sensory and motor cortices, while distractor responses were suppressed after primary somatosensory cortex (S1).

Keywords:

attenuating filter neocortex sensorimotor sensory selection somatosensory widefield imaging

More Related Videos

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain

Published on: October 11, 2017

Localization of the Locus Coeruleus in the Mouse Brain

Localization of the Locus Coeruleus in the Mouse Brain

Published on: March 7, 2019

Related Experiment Videos

Last Updated: Dec 19, 2025

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain

Published on: October 11, 2017

Localization of the Locus Coeruleus in the Mouse Brain

Localization of the Locus Coeruleus in the Mouse Brain

Published on: March 7, 2019

Area of Science:

Neuroscience
Cognitive Neuroscience
Sensory Processing

Background:

Goal-directed behavior requires selective responses to environmental stimuli.
Neural mechanisms for distinguishing target from distractor stimuli are not well understood.

Purpose of the Study:

Investigate the neural basis of sensory selection.
Identify brain regions involved in ignoring distractor stimuli.

Main Methods:

Mice trained on a selective whisker detection task.
Widefield Ca2+ imaging used to monitor neural activity in dorsal cortex.
Analysis of neural responses to target and distractor stimuli in expert mice.

Main Results:

Target stimuli evoked strong neural activation in primary somatosensory cortex (S1) and frontal motor areas (wMC, ALM).
Distractor stimuli activated S1 but showed minimal propagation to frontal cortex.
Robust attenuation of distractor processing occurred between S1 and wMC.

Conclusions:

Sensory selection involves suppression of distractor processing beyond S1.
The S1 to wMC pathway plays a key role in filtering irrelevant stimuli.
This study provides a model for understanding sensory selection and distractor suppression.