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Tardive syndromes.

Eoin Mulroy1, Bettina Balint2,3, Kailash P Bhatia2

  • 1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK eoin.mulroy@nhs.net.

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Summary
This summary is machine-generated.

Tardive syndromes, delayed movement disorders from dopamine receptor-blocking antipsychotics, manifest diversely. This review clarifies their understanding and offers clinical management guidance.

Keywords:
DEMENTIAMOVEMENT DISORDERSPUPILSSUPRANUCLEAR PALSYVISION

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Dopamine receptor-blocking antipsychotics, introduced in 1952, were initially seen as cures for psychiatric disorders.
  • However, acute and chronic drug-induced movement disorders were recognized within five years.
  • Tardive syndromes, characterized by delayed onset movement disorders, have diverse clinical presentations.

Purpose of the Study:

  • To review current knowledge on tardive syndromes.
  • To provide clinicians with practical guidance for managing these movement disorders.

Main Methods:

  • Literature review of tardive syndromes.
  • Synthesis of existing knowledge on pathophysiology and treatment.

Main Results:

  • Tardive syndromes present with varied symptoms including oro-bucco-lingual dyskinesia, dystonic posturing, and abnormal breathing.
  • The pathophysiologic basis of tardive syndromes remains poorly understood.
  • Optimal treatment strategies are still unclear.

Conclusions:

  • Despite decades of clinical practice, the understanding and management of tardive syndromes require further investigation.
  • This review aims to consolidate current knowledge and offer pragmatic clinical recommendations.