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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
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Sarcoidosis and the Nervous System.

Siddharama Pawate

    Continuum (Minneapolis, Minn.)
    |June 4, 2020
    PubMed
    Summary

    Neurosarcoidosis, a neurologic manifestation of sarcoidosis, requires biopsy for diagnosis. Infliximab shows promise for refractory cases, complementing established treatments like glucocorticoids and steroid-sparing agents.

    Area of Science:

    • Neurology
    • Immunology
    • Granulomatous Diseases

    Background:

    • Sarcoidosis is a multisystem immune-mediated granulomatous disease.
    • Neurosarcoidosis affects the nervous system in 5-25% of sarcoidosis cases.
    • Neurologic manifestations are diverse, affecting central and peripheral nervous systems.

    Purpose of the Study:

    • To provide an overview and update on neurologic manifestations of sarcoidosis.
    • To discuss diagnostic criteria and treatment strategies for neurosarcoidosis.

    Main Methods:

    • Review of current literature and diagnostic criteria.
    • Analysis of recent retrospective studies on treatment efficacy.

    Main Results:

    • The 2018 Neurosarcoidosis Consortium criteria highlight biopsy's importance for diagnosis.

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  • Definite neurosarcoidosis requires nervous system biopsy; probable requires extraneural biopsy.
  • Infliximab demonstrates efficacy in refractory neurosarcoidosis cases.

    • Conclusions:

    • Accurate diagnosis of neurosarcoidosis relies on established criteria and biopsy.
    • Glucocorticoids are primary treatment, with steroid-sparing agents for long-term management.
    • Anti-tumor necrosis factor agents like infliximab offer options for treatment-resistant neurosarcoidosis.