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Kirvis Torres-Poveda1, Patricia Piña-Sánchez2, Verónica Vallejo-Ruiz3
1Center for Research in Infectious Diseases, Instituto Nacional de Salud Pública, Cuernavaca, Mor., Mexico; Consejo Nacional de Ciencia y Tecnología (CONACyT)-Instituto Nacional de Salud Pública, Cuernavaca, Mor., Mexico.
Summary
High-risk human papillomavirus (HPV) infection is linked to cervical cancer (CC). New diagnostic and prognostic tools, including HPV detection and biomarkers, aid in early CC detection and management.
Area of Science:
- Oncology
- Virology
- Molecular Biology
Background:
- High-risk human papillomavirus (HPV) infection is a primary cause of cervical cancer (CC).
- Cellular changes induced by viral oncoproteins can lead to pre-malignant lesions and eventually CC.
- Early detection and risk stratification are crucial for managing CC development.
Purpose of the Study:
- To review current HPV detection and quantification methods.
- To explore secondary screening approaches for premalignant lesions and CC.
- To analyze validated and investigational biomarkers for CC risk classification and prognosis.
Main Methods:
- Review of HPV detection and quantification techniques.
- Analysis of secondary screening strategies.
- Evaluation of molecular biomarkers for triage and prognostic assessment.
Main Results:
- HPV DNA detection combined with molecular biomarkers offers a powerful tool for CC risk assessment.
- Biomarkers aid in classifying women at high risk for CC after initial HPV testing.
- Identified biomarkers can guide clinical management and may serve as therapeutic targets.
Conclusions:
- Integrated HPV testing and biomarker analysis significantly enhance diagnostic and prognostic capabilities for cervical cancer.
- These approaches are vital for identifying at-risk individuals and tailoring clinical management.
- Further research into biomarkers may lead to novel therapeutic strategies for cervical cancer.