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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Evaluation of Heat Effects on Transdermal Nicotine Delivery In Vitro and In Silico Using Heat-Enhanced Transport

Terri D La Count1, Qian Zhang1, Michael Murawsky1

  • 1Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, 45267, USA.

The AAPS Journal
|June 4, 2020
PubMed
Summary

Heating transdermal delivery systems (TDSs) significantly increases nicotine flux across skin. A combined experimental and computational model accurately predicts these heat effects on drug delivery from TDSs.

Keywords:
heat-enhancedhuman skinin vitro membrane transportmathematical modelnicotinetransdermal

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