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Updated: Dec 19, 2025

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound
O V Yur'eva1, V I Dubrovina2, V A Potapov3
1Irkutsk Antiplague Research Institute, Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Irkutsk, Russia.
Abstract:
We studied immunotropic properties of synthetic selenium-organic preparation 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonyl dibromide (974zh). The experimental preparation reduced the cAMP/cGMP ratio, which indicated an increase in proliferative activity of cells of immunocompetent organs (thymus and spleen) in experimental animals. It was shown that 974zh intensified the immune response to Yersinia pestis EV thereby increasing the resistance to the plague agent.

