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Increasing ovarian NAD+ levels improve mitochondrial functions and reverse ovarian aging

Qingling Yang1, Luping Cong1, Yujiao Wang1

  • 1Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Engineering Laboratory of Preimplantation Genetic Diagnosis and Screening, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Free Radical Biology & Medicine
|June 4, 2020
PubMed
Summary

Supplementing aging mice with nicotinamide riboside (NR), an NAD+ precursor, restored ovarian NAD+ levels, improving follicle count, ovulation, and live birth rates, offering a potential therapy for age-related infertility.

Keywords:
InfertilityMitochondriaNAD(+)Ovary aging

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