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Oxyresveratrol Possesses DNA Damaging Activity.

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Oxyresveratrol, a compound from Artocarpus lakoocha heartwood, shows pro-oxidant activity. This activity, involving DNA damage and reactive oxygen species generation in the presence of copper, may link it to anticancer properties.

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Biochemistry

Background:

  • Artocarpus lakoocha (Moraceae) is a traditional Thai medicine.
  • This plant species contains phytochemicals with potent biological activities.

Purpose of the Study:

  • To determine the phytochemical profile of A. lakoocha heartwood extracts.
  • To investigate the pro-oxidant activity of these extracts in vitro.

Main Methods:

  • Extraction and chromatographic/spectroscopic analyses of A. lakoocha heartwood.
  • Assays for DNA-nick, reactive oxygen species (ROS), and reducing activity.
  • Investigation of oxyresveratrol's activity in the presence of copper (II) ions.

Main Results:

  • Oxyresveratrol was identified as the major component in A. lakoocha heartwood extracts.
  • Oxyresveratrol induced dose-dependent DNA damage and ROS generation with copper (II) ions.
  • Oxyresveratrol reduced copper (II) to copper (I).

Conclusions:

  • Oxyresveratrol is the most abundant stilbenoid in A. lakoocha heartwood.
  • The compound exhibits pro-oxidant activity mediated by copper (II) ions.
  • This pro-oxidant activity may contribute to its potential anticancer effects.