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Related Experiment Videos

Recalcification time in breast disease.

C A Sofia, C R Spillert, J A Pastena

    Journal of the National Medical Association
    |November 1, 1988
    PubMed
    Summary
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    Breast cancer patients show increased tissue factor generation by monocytes, indicated by shorter recalcification times. This suggests a link between cancer and hypercoagulability, a state of increased blood clotting.

    Area of Science:

    • Oncology
    • Hematology
    • Immunology

    Background:

    • Malignant diseases are associated with hypercoagulability.
    • Monocytes play a role in this hypercoagulability through tissue factor generation.

    Purpose of the Study:

    • To investigate the procoagulant activity of monocytes in breast cancer patients.
    • To compare monocyte activation markers in breast cancer patients versus controls.

    Main Methods:

    • Venous blood samples were collected and anticoagulated.
    • Monocytes were activated with endotoxin.
    • Tissue factor generation was assessed using a recalcification time assay.

    Main Results:

    • Breast cancer patients exhibited significantly shorter endotoxin-activated recalcification times compared to healthy volunteers.

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  • Patients with cystic hyperplasia also showed reduced recalcification times compared to healthy volunteers, but longer than breast cancer patients.

    • Conclusions:

    • Monocytes in breast cancer patients demonstrate enhanced procoagulant activity.
    • This heightened activity may contribute to the hypercoagulability observed in malignancy.
    • The recalcification time assay serves as a marker for cellular activation in cancer-related coagulation disorders.