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A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Published on: November 12, 2020
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Takayasu's arteritis: Ischaemic retinal arterial occlusion as a possible initial presentation
J L Sánchez-Vicente1, F E Molina-Sócola2, J De Las Morenas-Iglesias3
1Licenciado en Medicina y Cirugía. Servicio de Oftalmología, Hospital Universitario Virgen del Rocío de Sevilla, Sevilla, España; Hospital Universitario Virgen del Rocío. Oftalmología, sección de Retina Quirúrgica. Sevilla, Sevilla, España.
Archivos De La Sociedad Espanola De Oftalmologia
|June 5, 2020
Summary
Takayasu's arteritis can present with vision loss due to retinal arterial occlusion. Early diagnosis is crucial, as ophthalmological signs may be the first indication of this rare arterial disease.
Area of Science:
- Vascular Inflammation
- Ophthalmology
- Rheumatology
Background:
- Takayasu's arteritis is a rare, chronic inflammatory disease affecting large arteries, primarily the aorta and its branches.
- Ocular manifestations occur in approximately 25% of patients and can be diverse.
Observation:
- A 41-year-old woman experienced progressive vision loss in her right eye due to ischemic retinal arterial occlusion.
- Initial investigations revealed a positive purified protein derivative (PPD) skin test, leading to a suspicion of tuberculous retinal vasculitis.
- Treatment for tuberculous retinal vasculitis with antimicrobials and corticosteroids was ineffective.
Findings:
- The patient later developed acute kidney failure secondary to right renal artery stenosis.
- CT-angiography demonstrated thickening of the aortic arch and its branches, confirming a diagnosis of Takayasu's arteritis.
- This case highlights the diagnostic challenges and the potential for ocular symptoms to precede other systemic manifestations.
Implications:
- Ophthalmologists play a critical role in the early detection of Takayasu's arteritis.
- Ophthalmological findings can serve as an early warning sign for this potentially debilitating condition.
- Prompt recognition of ocular signs can lead to earlier diagnosis and management of Takayasu's arteritis, potentially preventing severe systemic complications.
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