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Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
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MIPPIE: the mouse integrated protein-protein interaction reference.

Gregorio Alanis-Lobato1,2, Jannik S Möllmann1, Martin H Schaefer3

  • 1Faculty of Biology, Johannes Gutenberg University, Biozentrum I, Hans-Dieter-Hüsch-Weg 15, 55128 Mainz, Germany.

Database : the Journal of Biological Databases and Curation
|June 5, 2020
PubMed
Summary
This summary is machine-generated.

Researchers developed MIPPIE, a new database for mouse protein-protein interactions (PPIs). This resource aids in understanding cellular functions and diseases by providing reliable mouse PPI networks for bioinformatics analysis.

Keywords:
Mus musculusdatabasemouseprotein interaction networkprotein-protein interactions

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Area of Science:

  • * Molecular Biology
  • * Bioinformatics
  • * Systems Biology

Background:

  • * Cellular function relies on complex protein-protein interactions (PPIs).
  • * Malfunctioning PPIs disrupt cellular homeostasis, contributing to diseases.
  • * The house mouse (Mus musculus) is a crucial model organism for studying human biology and diseases.

Purpose of the Study:

  • * To develop a comprehensive reference database for mouse protein-protein interactions.
  • * To facilitate the analysis of mouse PPI networks for biological and disease research.
  • * To provide a user-friendly platform for accessing and refining mouse PPI data.

Main Methods:

  • * Development of the Mouse Integrated Protein-Protein Interaction rEference (MIPPIE) database.
  • * Inheritance of robust infrastructure from the human PPI database HIPPIE.
  • * Integration of diverse evidence sources and high-quality experimental techniques.
  • * Implementation of a user-friendly web interface for network refinement (tissue, directionality, effect).
  • * Provision of data access via REST web service and downloadable text files.

Main Results:

  • * MIPPIE provides reliable mouse PPI networks.
  • * Networks can be refined with specific biological context (tissue, directionality, effect).
  • * Data is accessible through multiple formats, supporting bioinformatics pipelines.

Conclusions:

  • * MIPPIE is a valuable resource for studying mouse PPI networks.
  • * The database enhances understanding of cellular processes and disease mechanisms in mice.
  • * MIPPIE facilitates the integration of mouse PPI data into broader research efforts.