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Updated: Dec 19, 2025

Microtiter Dish Biofilm Formation Assay
Published on: January 30, 2011
Staphylococcal Vaccine Antigens related to biofilm formation
Bahman Mirzaei1,2, Ryhaneh Babaei2, Sina Valinejad2
1Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences , Sari, Iran.
Abstract:
The number and frequency of multidrug-resistant (MDR) strains as a frequent cause of nosocomial infections have increased, especially for Methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis, in part due to device-related infections. The transition to antibiotic-resistance in related bacterial genes and the capability for immune escape have increased the sustainability of biofilms produced by these bacteria. The formation and changes in biofilms have been suggested as a target to prevent or treat staphylococcal infections. Thus, this study reviews the development of candidate staphylococcal vaccines by database searching, and evaluates the immunogenicity and efficacy profiles of bacterial components involved in biofilms. The literature suggests that using common staphylococcal vaccine antigens and multivalent vaccines should further enhance vaccine efficacy.
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