Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.5K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.5K
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

328
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
328
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

148
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
148
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

100
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
100

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydrogels of dialdehyde starch and gelatin cross-linked with potential application as tissue adhesives.

International journal of biological macromolecules·2024
Same author

Structural and physicochemical properties of corn starch modified by phosphorylase b, hexokinase and alkaline phosphatase.

Carbohydrate polymers·2024
Same author

Effects of different ratios of water and glycerol on the physicochemical properties of starch-based straws.

Food chemistry·2024
Same author

Effects of different ratios of glycerol to erythritol on the structure and properties of starch straws during long term storage.

Food chemistry·2024
Same author

Roles of mTOR-p70S6K signaling pathway and HO-1 in ethylbenzene-induced hepatoxic effects in L02 cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2024
Same author

Starch/polyacrylamide hydrogels with flexibility, conductivity and sensitivity enhanced by two imidazolium-based ionic liquids for wearable electronics: Effect of anion structure.

Carbohydrate polymers·2024

Related Experiment Video

Updated: Dec 19, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.5K

Construction and characterization of avermectin B2 solid nanodispersion.

Bo Cui1, Fei Gao1, Zhanghua Zeng1

  • 1Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

Scientific Reports
|June 6, 2020
PubMed
Summary
This summary is machine-generated.

A novel solid nanodispersion formulation for avermectin B2 significantly enhances pesticide bioavailability and efficacy. This eco-friendly approach reduces pesticide dosage and environmental impact by improving wettability.

More Related Videos

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
09:35

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization

Published on: December 25, 2017

29.1K
Nanosponge Tunability in Size and Crosslinking Density
11:15

Nanosponge Tunability in Size and Crosslinking Density

Published on: August 4, 2017

8.0K

Related Experiment Videos

Last Updated: Dec 19, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.5K
Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
09:35

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization

Published on: December 25, 2017

29.1K
Nanosponge Tunability in Size and Crosslinking Density
11:15

Nanosponge Tunability in Size and Crosslinking Density

Published on: August 4, 2017

8.0K

Area of Science:

  • Agricultural Chemistry
  • Nanotechnology
  • Pesticide Formulation

Background:

  • Poorly water-soluble pesticides present formulation challenges, leading to low efficacy and environmental loss.
  • Conventional pesticide formulations often result in over 50% loss during application due to decomposition, dust drift, and runoff.
  • There is a critical need for advanced formulations to improve pesticide bioavailability and reduce environmental contamination.

Purpose of the Study:

  • To develop a novel, environmentally friendly nanoformulation for avermectin B2 with enhanced efficacy.
  • To investigate the relationship between formulation properties (particle size, surface tension, contact angle) and pesticide bioavailability.
  • To evaluate the toxicity of the developed nanoformulation against key agricultural pests.

Main Methods:

  • Avermetcin B2 solid nanodispersion was synthesized using self-emulsifying and solidification techniques.
  • Characterization of the nanodispersion included measurement of particle size, surface tension, and contact angle on cabbage leaves.
  • Efficacy was assessed by comparing the toxicity of the nanoformulation against diamondback moths and root-knot nematodes with conventional formulations.

Main Results:

  • The avermectin B2 solid nanodispersion exhibited an average particle size of 35.3 nm.
  • Surface tension and contact angle on cabbage leaves were measured at 36.6 mN/m and 58°, respectively.
  • The nanoformulation demonstrated over 1.7 times higher toxicity against pests compared to conventional emulsion and water dispersible granule formulations.

Conclusions:

  • Pesticide bioavailability for foliar application is positively correlated with wettability, which is inversely related to surface tension and contact angle.
  • The developed solid nanodispersion offers an effective, scalable, and environmentally friendly approach to pesticide formulation.
  • This nanoformulation significantly enhances toxicity, potentially reducing pesticide dosage and environmental pollution, and provides insights for future pesticide design.