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Related Experiment Video

Updated: Dec 19, 2025

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

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Extendable, large-field multi-modal optical imaging system for measuring tissue hemodynamics.

Chen Wang1,2, Xiao Chen1,2, Jiachi Hong1,2

  • 1Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.

Biomedical Optics Express
|June 6, 2020
PubMed
Summary

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This study presents a novel multimodal imaging system for simultaneously measuring tissue blood flow, oxygenation, and hemoglobin concentrations. The system enhances the exploration of macroscopic tissue hemodynamics in various physiological and pathological conditions.

Area of Science:

  • Biomedical Optics
  • Physiological Imaging
  • Tissue Optics

Background:

  • Simultaneous imaging of multiple hemodynamic parameters is crucial for assessing tissue physiological and pathological states.
  • Existing methods often lack a large field of view or simultaneous multi-parameter detection.

Purpose of the Study:

  • To develop and validate a multimodal hemodynamics imaging system with a large field of view.
  • To simultaneously detect changes in blood flow, oxygenation, and hemoglobin concentrations.

Main Methods:

  • Designed an infinite conjugate relay lens system for multi-wavelength imaging with a single camera lens and multiple CCD/CMOS cameras.
  • Integrated dual wavelength reflectance imaging and laser speckle contrast imaging.
  • Developed an integral algorithm to improve hemoglobin concentration measurement accuracy by considering differential pathlength factors and spectral characteristics.

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Related Experiment Videos

Last Updated: Dec 19, 2025

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

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Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
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Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Published on: December 8, 2010

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Main Results:

  • Successfully combined dual wavelength reflectance imaging and laser speckle contrast imaging.
  • Validated the system using phantom and in vivo experiments, including arterial occlusion.
  • Demonstrated detection of blood volume pulse and blood flow pulse signals in human subjects.

Conclusions:

  • The developed imaging system enables simultaneous, large-field-of-view measurement of multiple hemodynamic parameters.
  • This system facilitates the exploration of macroscopic tissue hemodynamics.
  • The integral algorithm enhances the accuracy of hemoglobin concentration measurements.