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NAD metabolism in aging and cancer

John Wr Kincaid1,2, Nathan A Berger2,3,4,5,6

  • 1Department of Nutrition, 12304Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Experimental Biology and Medicine (Maywood, N.J.)
|June 6, 2020
PubMed
Abstract

Insights

Nicotinamide adenine dinucleotide (NAD) is crucial for energy, growth, and DNA stability. Understanding NAD metabolism pathways and related enzymes is key for preventing and treating diseases like cancer and aging.

Area of Science:

  • Biochemistry
  • Metabolic pathways
  • Molecular biology

Background:

  • Nicotinamide adenine dinucleotide (NAD) is a vital metabolite linking cellular energy, growth, genomic stability, and aging.
  • NAD plays a critical role in the development of malignancy and aging processes.
  • Enzymes involved in NAD metabolism are central to these physiological and pathological functions.

Purpose of the Study:

  • To elucidate the complex pathways of NAD metabolism.
  • To highlight the diverse enzymatic machinery regulating NAD.
  • To underscore the significance of NAD metabolism in disease prevention and progression.

Main Methods:

  • Review of NAD biosynthesis pathways.
  • Analysis of NAD utilization by various enzymes.
  • Description of enzyme classes including dehydrogenases, hydrolases, transferases, polymerases, and sirtuins.

Main Results:

  • NAD metabolism involves intricate biosynthesis and utilization pathways.
  • A wide array of enzymes, including dehydrogenases, PARPs, and sirtuins, regulate NAD.
  • Perturbations in these pathways are implicated in disease.

Conclusions:

  • NAD metabolism is a fundamental biological process with broad implications.
  • Understanding NAD pathways offers potential for novel therapeutic strategies.
  • Targeting NAD metabolism may be crucial for disease intervention and management.
Keywords:
NADagingcancermono(ADP-ribose)poly(ADP-Ribose)sirtuins

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