Biomedical invasive pressure sensor coatings: calibration and waveform perspectives

The biocompatibility of invasive biomedical sensors is a fundamental issue in the design of implanted sensors. Therefore, the unique packaging of the sensor is a crucial design procedure that must be performed and evaluated correctly. Under steady-state measurements, the sensor calibration can be done quickly, and the corresponding errors and loss in the sensor's sensitivity, because of the packaging material, can be compensated easily. This paper investigates the effect of the presence and absence of biocompatible silicone paste as packaging material on the catheter sensor's output waveform morphology, and the sensor's response time under dynamic measurements. The procedure to calibrate the sensor during the design is presented to compensate for the effect of packaging material in terms of state-space formulation. In conclusion, errors in peak pressure and waveform shape in the catheter sensor can be significantly reduced by the geometry and the packaging materials of the catheter sensor. At last, we believe that using biocompatible silicone paste as packaging material on the catheter sensor is scalable.