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Updated: Dec 19, 2025
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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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[Acute disseminated encephalomyelitis and severe post-infectious encephalitis].
1Service de réanimation médicale et des maladies infectieuses, hôpital Bichat-Claude-Bernard, AP-HP, université Paris-7, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.
Summary
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated CNS disorder following infection. Diagnosis relies on MRI, with steroids as primary treatment for this inflammatory demyelinating condition.
Area of Science:
- Neurology
- Immunology
- Pathology
Context:
- Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disorder of the central nervous system (CNS).
- It is often preceded by a minor infection, suggesting an immune-mediated mechanism.
- ADEM presents with acute neurological deficits and encephalopathy.
Purpose:
- To describe the clinical characteristics, diagnostic methods, and therapeutic approaches for ADEM.
- To highlight the role of neuroimaging and differentiate ADEM from infectious encephalitis.
- To discuss the typical outcomes and potential for recurrent forms of ADEM.
Summary:
- ADEM is characterized by acute neurological signs and encephalopathy, often following infection.
- Diagnosis is primarily based on cerebral MRI, revealing characteristic white matter lesions.
- Treatment typically involves high-dose intravenous steroids, with plasma exchange and IVIg as potential adjuncts.
Impact:
- Provides a concise overview of ADEM for clinicians and researchers.
- Emphasizes the importance of MRI in diagnosing this immune-mediated neurological disorder.
- Informs therapeutic strategies and understanding of ADEM prognosis.
