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Updated: Dec 19, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
Comprehensive analysis of microenvironment-related genes in lung adenocarcinoma
Ye Tao1, Yunhui Li2, Bin Liang1
1Bioinformatics of Department, Key laboratory of Cell Biology, Ministry of Public Health, & Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang 110122, PR China.
Abstract:
Aim: Understanding the cell types and cell compositions in tumor environment (TME) and the gene changes in lung adenocarcinoma (LUAD) may provide insights on immune profiles and treatment targets for LUAD patients. Materials & methods: The RNA-Seq data from The Cancer Genome Atlas database were used to calculate the stromal scores and immune scores and analyzed the fractions of tumor infiltrating immune cells in LUAD samples with ESTIMATE and CIBERSORT algorithm. Results: We extracted a list of TME-related differentially expressed genes and performed the functional enrichment analysis. We found these genes were mainly enriched in immune response and cancer-related signal pathways. The prognosis analysis indicated that LINC00211, MUC2, LINC00426, LY86-AS1 ZEB2-AS1 and EREG were associated with prognosis in LUAD patients. Conclusion: The current study provides novel insights into immune files and gene changes in TME in LUAD patients.
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