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[Herpetic infection (Herpes simplex].

A V Tsinzerling, M G Indikova

    Arkhiv Patologii
    |January 1, 1988
    PubMed
    Summary
    This summary is machine-generated.

    Herpes simplex virus (HSV) infections in neonates are frequent, with similar structural lesions observed in both Type I and II herpes simplex. Prenatal and postnatal infections reveal distinct cellular changes in organs like the brain and lungs.

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    Area of Science:

    • Virology
    • Pathology
    • Microscopy

    Context:

    • Herpesviridae infections, particularly herpes simplex virus (HSV), pose significant risks, especially in neonatal populations.
    • Understanding the structural pathology of HSV is crucial for diagnosis and management.

    Purpose:

    • To analyze and investigate the structural manifestations, transmission, and entry modes of Herpesviridae, focusing on herpes simplex.
    • To evaluate visceral changes in prenatal and placental HSV infections and compare them with postnatal infections.

    Summary:

    • Generalized herpetic infection was found in 4.7% of neonatal cases.
    • Lesions from Type I and II herpes simplex were structurally similar.
    • Prenatal/placental infections showed epithelial cell affection with nuclear inclusions; brain and lung tissues exhibited distinct pathological alterations.

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    Impact:

    • Provides detailed insights into the histopathology of neonatal herpes simplex virus infections.
    • Highlights the importance of microscopy and serological tests in diagnosing herpesviridae infections.
    • Contributes to understanding the varied organ-specific damage caused by HSV.