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Updated: Aug 11, 2026
05:51
Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
[Infectious toxic shock in generalized rotaviral infection in newborns]
Arkhiv Patologii
|January 1, 1993
Summary
Rotavirus infection can generalize in newborns, leading to fatal outcomes from infectious toxic shock and disseminated intravascular coagulation. Giant cell metamorphosis and viremia were observed, indicating severe systemic spread.
Area of Science:
- Virology
- Neonatal Pathology
Background:
- Rotavirus is a common cause of gastroenteritis in infants.
- Severe rotavirus infections can lead to systemic complications.
Observation:
- Three newborn deaths were linked to generalized rotavirus infection.
- Infectious toxic shock and DIC complicated the fatal cases.
- Giant cell metamorphosis was noted in multiple organs, suggesting viremia.
Findings:
- Electron microscopy, immunoenzymatic, and immunofluorescent methods confirmed rotavirus etiology.
- Co-infection with respiratory syncytial virus exacerbated the pathology.
- Necrotizing enterocolitis, perforative peritonitis, and hemorrhage were observed.
Implications:
- This study highlights the potential for severe, systemic rotavirus disease in neonates.
- Early detection and management of rotavirus and co-infections are critical.
- Understanding viremia in rotavirus is crucial for preventing fatal outcomes.
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