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Published on: April 3, 2016
[Choroidal thickness in children with myopia and its changes after surgical strengthening of the sclera]
E P Tarutta1, G A Markossian1, A A Sianosyan1
1Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia.
Insights
Sclera reinforcement surgery significantly increased choroidal thickness (CT) in children, suggesting it boosts collagen synthesis and inhibits myopia progression. This finding offers new insights into myopia management strategies.
Area of Science:
- Ophthalmology
- Pediatric ophthalmology
- Retinal research
Background:
- Choroidal thickness (CT) is a key indicator in refractive error development.
- Myopia progression in children is a significant public health concern.
- Sclera reinforcement surgeries aim to control myopia progression.
Purpose of the Study:
- To investigate choroidal thickness (CT) in pediatric myopia and hyperopia.
- To evaluate changes in CT following sclera reinforcement surgeries.
- To explore the relationship between CT changes and myopia progression.
Main Methods:
- Study included 133 children with myopia or hyperopia.
- Choroidal thickness measured using enhanced depth imaging spectral-domain optical coherence tomography (EDI-SD-OCT).
- Compared CT before and after low invasive scleroplasty (LSP) or bandaging scleroplasty (BSP).
Main Results:
- A reduction in CT was observed with refractive error progression and axial elongation in 78 patients.
- Operated eyes showed significant CT increase: 42.5±3.17 μm after LSP and 62.1±1.06 μm after BSP.
- Fellow eyes also exhibited increased CT: 26.1±1.79 μm after LSP and 33.7±0.55 μm after BSP.
Conclusions:
- Sclera reinforcement surgery leads to a significant early increase in CT in both operated and fellow eyes.
- Increased CT may stimulate scleral collagen synthesis and activity.
- This CT increase potentially enhances the inhibitory effect of scleroplasty on myopia progression.
Purpose:
To study the choroidal thickness (CT) in children with myopia and hyperopia and its changes after sclera reinforcement surgeries addressing the progression of myopia.
Material And Methods:
The study involved 133 patients: 78 children (average age 12.5±0.35 years) with mild hyperopia, low, moderate and high myopia and 55 children with moderate and high myopia who received low invasive scleroplasty (LSP, average age 12.31±0.49 years), or bandaging scleroplasty (BSP, average age 12.59±0.24 years) according to Snyder-Thompson technique and were examined prior to and after the procedure. All patients underwent standard ophthalmologic examination and had choroidal thickness manually measured with EDI-SD-OCT; 55 patients were examined before and 1 week after scleroplasty.
Results:
A reduction of CT with refraction growth and axial elongation was found in 78 patients. Among the 55 patients, changes in CT were statistically significant: in the operated eyes, CT increased by 42.5±3.17 μm after LSP and by 62.1±1.06 μm after BSP. In fellow eyes, CT showed an increase of 26.1±1.79 μm after LSP and 33.7±0.55 μm after BSP.
Conclusion:
In the early period after sclera strengthening, CT significantly increased both in the operated and in the fellow eye. An increase of CT seems to stimulate the collagen biosynthetic activity of the scleral matrix and the collagen synthesis, and to boost the inhibitory effect that scleroplasty has on the myopia progression.
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