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Chronic hepatitis C virus infection and genitourinary cancers: A case-control study
Georgios Angelidakis1, Parag Mahale1, Eric Jonasch2
1Departments of Infectious Diseases, Infection Control and Employee Health.
Seminars in Oncology
|June 9, 2020
Summary
This study found no link between Hepatitis C virus (HCV) infection and common genitourinary cancers like kidney, prostate, or bladder cancer. Further research is needed to understand potential associations.
Area of Science:
- Hepatology and Oncology
- Viral Oncology
- Genitourinary Cancer Research
Background:
- Chronic Hepatitis C virus (HCV) infection is linked to extrahepatic cancers, but associations with genitourinary cancers remain unclear.
- This study investigated the relationship between HCV and common genitourinary cancers, including kidney, prostate, and urinary bladder cancers.
Discussion:
- A case-control study analyzed anti-HCV antibody prevalence in patients with genitourinary cancers versus those with smoking-associated cancers.
- Multivariate logistic regression was employed to control for confounding factors.
Key Insights:
- Univariate analysis showed no significant difference in anti-HCV prevalence for renal pelvis, prostate, or urinary bladder cancers compared to controls.
- Kidney cancer cases had a lower anti-HCV prevalence than controls in univariate analysis.
- Multivariate analyses revealed no significant association between anti-HCV positivity and any of the studied genitourinary cancers.
Outlook:
- The findings do not support a link between chronic HCV infection and the evaluated common genitourinary cancers.
- Further research may explore other genitourinary cancers or specific HCV genotypes.
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