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Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
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Related Experiment Video

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Dynamics of digital ulcers in systemic sclerosis.

Carmen Bobeică1,2, Alin Laurențiu Tatu3,4, Mihaela Crăescu2,5

  • 1Department of Dermato-Venereology, Doctoral School, University of Medicine and Pharmacy 'Gr. T. Popa' Iaşi, 700115 Iaşi, Romania.

Experimental and Therapeutic Medicine
|June 9, 2020
PubMed
Summary

Systemic sclerosis (SSc) involves vasculopathy and fibrosis, impacting quality of life. This study observed digital ulcers and fibrotic signs in 22 SSc patients, finding no direct causality between these aspects.

Keywords:
Raynaud's phenomendigital ulcersmicroangiopatymicrostomiamicrovasculopathysystemic sclerosis

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Area of Science:

  • Rheumatology
  • Immunology
  • Dermatology

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease with poorly understood origins.
  • It features microvasculopathy, excessive fibrosis, and significant impacts on patient quality of life.
  • Limited therapeutic options necessitate a deeper understanding of SSc pathogenesis.

Purpose of the Study:

  • To investigate the relationship between vasculopathy (digital ulcers) and fibrosis in Systemic sclerosis.
  • To correlate clinical and paraclinical data for improved disease management.
  • To explore the interplay of Raynaud phenomenon, microstomia, and digital contractures with disease manifestations.

Main Methods:

  • An observational study involving 22 hospitalized Systemic sclerosis patients.
  • Evaluation of digital ulcer evolution as a marker of vasculopathy.
  • Correlation of digital ulcer status and dynamics with fibrotic clinical indicators.

Main Results:

  • Raynaud phenomenon is nearly universal in SSc but not always linked to digital ulcers.
  • No causal link was established between fibrosis and vasculopathy in this cohort.
  • Microstomia and digital contractures occurred with and without digital ulcers.

Conclusions:

  • The pathogenesis of Systemic sclerosis is multifactorial with many unknown elements.
  • Further research is needed to elucidate SSc mechanisms for targeted therapies.
  • Observing individual patient data is crucial for optimizing SSc management.