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Related Experiment Video

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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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From Blood Count Parameters to ROP Risk: Early Hematological Predictors in Preterm Infants.

Laura Bujoreanu Bezman1,2, Carmen Tiutiuca2,3, Florin Ciprian Bujoreanu2

  • 1Department of Ophthalmology, "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania.

Medicina (Kaunas, Lithuania)
|September 27, 2025
PubMed
Summary

Anemia and thrombocytopenia in preterm infants, along with blood transfusions, are linked to a higher risk of retinopathy of prematurity (ROP). Monitoring these hematological markers can improve early ROP detection and prevention strategies.

Keywords:
ROPanemiabiomarkersblood transfusionshematological predictorsrisk factorsthrombocytopenia

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Area of Science:

  • Neonatology
  • Ophthalmology
  • Hematology

Background:

  • Retinopathy of prematurity (ROP) is a leading cause of preventable childhood blindness.
  • Hematological markers are emerging as key indicators for predicting ROP risk.
  • Early detection and intervention are crucial for mitigating visual impairment in ROP.

Purpose of the Study:

  • To investigate the association between hemoglobin levels, red blood cell count, platelet count, and blood transfusions with the risk of developing ROP.
  • To identify novel prognostic factors for ROP in preterm infants.
  • To refine ROP risk prediction models using hematological parameters.

Main Methods:

  • Retrospective study of 140 preterm infants (gestational age ≤ 34 weeks).
  • Sequential monitoring of hematological parameters during the first 28 days of life.
  • ROP screening conducted per international guidelines; statistical analyses performed.

Main Results:

  • Anemia was significantly more prevalent in infants with ROP (83.1% vs. 60.3%), increasing ROP risk (OR = 3.239).
  • Red blood cell and platelet transfusions were associated with higher ROP likelihood (OR = 3.088 and OR = 2.807, respectively).
  • Thrombocytopenia was linked to an elevated ROP risk (OR = 3.542), with lower platelet counts observed on days 7, 14, and 21 in the ROP group.

Conclusions:

  • Early hematological imbalances, including anemia and thrombocytopenia, significantly increase ROP risk.
  • The need for blood product transfusions is also a significant risk factor for ROP.
  • Integrating hematological marker monitoring into ROP screening protocols can enhance early identification and targeted management of vulnerable infants.