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Updated: Dec 19, 2025

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
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T lymphocytes in IgA nephropathy.

Yuyan Tang1, Haidong He1, Pin Hu1

  • 1Department of Nephrology, Minhang Hospital, Fudan University, Shanghai 201199, P.R. China.

Experimental and Therapeutic Medicine
|June 9, 2020
PubMed
Summary

Immunoglobulin A nephropathy (IgAN) involves abnormal IgA1 deposition. This review highlights T lymphocytes

Area of Science:

  • Nephrology
  • Immunology
  • Pathogenesis of IgAN

Background:

  • Immunoglobulin A nephropathy (IgAN) is the leading cause of end-stage renal disease globally.
  • Pathogenesis involves galactose-deficient IgA1 (Gd-IgA1) deposition in the renal mesangium.
  • The precise origin of Gd-IgA1 remains unclear, but mucosal immunity and T cell dysregulation are implicated.

Purpose of the Study:

  • To review recent discoveries on the role of T lymphocytes in IgAN pathogenesis.
  • To elucidate the contribution of T cells to Gd-IgA1 production and deposition.
  • To identify potential therapeutic targets for IgAN based on T cell involvement.

Main Methods:

  • Review of current literature on IgAN pathogenesis.
  • Analysis of studies investigating T cell subsets and their functions in IgAN.
Keywords:
B lymphocyteIgA nephropathyT lymphocytegalactose-deficient IgA1pathogenesis

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  • Synthesis of findings linking T cell dysregulation to Gd-IgA1 production.

    • Main Results:

    • T cells are crucial in the IgA response and IgAN development.
    • Gd-IgA1 deposition is associated with mucosally primed plasma cells and T cell dysregulation.
    • Specific T cell pathways contribute to the accumulation of pathogenic IgA1 in the kidneys.

    Conclusions:

    • T lymphocytes play a significant role in the pathogenesis of IgAN.
    • Understanding T cell involvement offers new avenues for IgAN treatment.
    • Targeting T cell dysregulation may lead to novel therapeutic strategies for IgAN.