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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Related Experiment Video

Updated: Dec 19, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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Characterization and Function of Circular RNAs in Plants.

Peijing Zhang1, Sida Li1, Ming Chen1,2

  • 1Department of Bioinformatics, State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China.

Frontiers in Molecular Biosciences
|June 9, 2020
PubMed
Summary

Circular RNAs (circRNAs) are crucial regulatory molecules in plants, impacting growth and stress responses. Research on plant circRNAs is rapidly advancing, revealing their unique features and functions compared to animals.

Keywords:
bioinformaticscharacterizationcircRNAcircularizationplantregulationstress response

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Last Updated: Dec 19, 2025

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Area of Science:

  • Molecular Biology
  • Genomics
  • Plant Science

Background:

  • Circular RNAs (circRNAs) are endogenous non-coding RNAs with diverse regulatory roles in eukaryotes.
  • While extensively studied in animals, plant circRNA research is a rapidly developing field.
  • Plant circRNAs are implicated in regulating gene transcription, alternative splicing, and interactions with miRNAs and proteins.

Purpose of the Study:

  • To review the biogenesis and characteristics of plant circRNAs.
  • To highlight available bioinformatics resources for plant circRNA analysis.
  • To summarize the biological functions and distinct features of plant circRNAs compared to animal circRNAs.

Main Methods:

  • Literature review of circRNA research in plants.
  • Analysis of existing databases and bioinformatics tools for plant circRNAs.
  • Comparative analysis of plant and animal circRNA biogenesis and expression patterns.

Main Results:

  • Numerous plant circRNAs have been identified and characterized.
  • Plant circRNAs play significant roles in plant growth, development, and stress responses.
  • Distinct circularization features and differential expression patterns exist between plant and animal circRNAs.

Conclusions:

  • Plant circRNAs represent a vital regulatory layer in plant biology.
  • Ongoing development of bioinformatics tools facilitates plant circRNA research.
  • Further investigation into plant circRNAs promises deeper insights into plant molecular mechanisms.