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CD3+ T cells are critical for the resolution of comorbid inflammatory pain and depression-like behavior

Geoffroy Laumet1, Jules D Edralin1, Robert Dantzer1

  • 1Laboratories of Neuroimmunology, Department of Symptom Research, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Neurobiology of Pain (Cambridge, Mass.)
|June 9, 2020
PubMed

Insights

T cells are crucial for resolving chronic pain and depression after inflammation. Restoring T cells in mice lacking them normalized pain and depression behaviors, highlighting their role in recovery.

Area of Science:

  • Immunology
  • Neuroscience
  • Pain Research

Background:

  • Chronic pain and depression frequently co-occur, but underlying mechanisms remain unclear.
  • Investigated the role of CD3+ T cells in a mouse model of inflammatory pain and depression.

Purpose of the Study:

  • To elucidate the function of T cells in the resolution of comorbid pain and depression.
  • To determine if T cells are involved in the onset or resolution phases of these conditions.

Main Methods:

  • Compared wild-type (WT) and T cell-deficient (Rag2-/-) mice following Complete Freund's Adjuvant (CFA) injection.
  • Assessed mechanical allodynia, spontaneous pain, and depression-like behaviors using established behavioral tests.

Main Results:

  • T cell-deficient mice showed delayed resolution of pain and depression behaviors.
  • Reintroducing T cells into deficient mice restored normal resolution timelines.
  • T cells did not influence the initial onset or severity of pain and depression behaviors.

Conclusions:

  • T cells are essential for the resolution of inflammatory pain and depression-like behaviors.
  • Dysregulation of T cell-mediated resolution may contribute to chronic pain and depression comorbidity.
  • Targeting T cell pro-resolution pathways offers potential therapeutic strategies for these conditions.
Abstract

Keywords:
CFAComorbidityDepression-like behaviorInflammatory painRecoveryT cells

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