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Updated: Dec 19, 2025

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
VenaSeal closure despite allergic reaction to n-butyl cyanoacrylate
Leslie Fiengo1, Adam Gwozdz1, Laura Tincknell1
1Academic Department of Vascular Surgery, School of Cardiovascular Medicine and Science, St Thomas' Hospital, King's College London, London, United Kingdom.
Abstract:
The VenaSeal closure system (Medtronic, Minneapolis, Minn) is a nonthermal, minimally invasive method for the treatment of superficial venous insufficiency using a proprietary n-butyl cyanoacrylate. We report the case of a 45-year-old woman who underwent right great saphenous vein closure with VenaSeal and subsequently had a biphasic reaction to n-butyl cyanoacrylate, confirmed on patch testing that had negative results for other cyanoacrylates. Despite the initial allergic response, which settled with antihistamines, follow-up duplex ultrasound imaging confirmed successful great saphenous vein closure, and the affected vein remained in situ without further complication.
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