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Continuous Wound Infiltration With Ropivacaine After Mastectomy: A Randomized Controlled Trial.

Marie Beguinot1, Emilie Monrigal2, Fabrice Kwiatkowski3

  • 1Département d'oncologie, Médipôle Hôpital Mutualiste Lyon Villeurbanne, Villeurbanne, France.

The Journal of Surgical Research
|June 9, 2020
PubMed
Summary
This summary is machine-generated.

Continuous wound infiltration with ropivacaine effectively reduces acute postoperative pain after mastectomy. However, it did not improve long-term quality of life or chronic pain levels in patients.

Keywords:
Breast cancerMastectomyPostoperative painRopivacaineWound infusion

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Area of Science:

  • Anesthesiology
  • Surgical Oncology
  • Pain Management

Background:

  • Postoperative pain is a significant concern for patients undergoing mastectomy.
  • Effective pain management strategies are crucial for patient recovery and well-being.

Purpose of the Study:

  • To evaluate the efficacy of continuous wound infiltration with ropivacaine in reducing acute postoperative pain.
  • To assess the impact of ropivacaine infiltration on long-term pain and quality of life after mastectomy.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving 150 mastectomy patients.
  • Patients received continuous ropivacaine (0.2%) or saline infusion for 48 hours post-surgery.
  • Postoperative morphine consumption, Visual Analog Scale (VAS) pain scores, and quality of life were recorded.

Main Results:

  • Ropivacaine infiltration significantly reduced VAS pain scores within the first 24 hours post-surgery.
  • A trend towards reduced morphine consumption was observed in the ropivacaine group within 48 hours (P=0.056), with significant reduction at day 1 (P=0.0026).
  • No significant differences in VAS pain scores or quality of life were found at 1, 3, or 6 months post-surgery.

Conclusions:

  • Continuous wound infiltration with ropivacaine is effective for managing acute postoperative pain following mastectomy.
  • Ropivacaine wound infiltration does not appear to improve long-term quality of life or reduce chronic pain after mastectomy.