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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Dec 19, 2025

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
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Cutaneous metastases: A great imitator.

Joanna Jaros1, Samantha Hunt2, Eucabeth Mose3

  • 1Department of Internal Medicine, AMITA St. Joseph Hospital, Joliet, Illinois, USA.

Clinics in Dermatology
|June 10, 2020
PubMed
Summary

Skin metastases, cancer spread to the skin, indicate a poor prognosis. Diagnosis requires high clinical suspicion and biopsy, with treatment options including surgery, chemotherapy, and palliative care.

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Neoplastic cells can spread to the skin from primary cancers, signaling a poor patient prognosis.
  • Common primary sources in women include melanoma, breast, ovarian, oral cavity, and lung cancers; in men, melanoma, lung, colon, and head and neck squamous cell carcinoma.
  • Cutaneous metastases present classically as firm, painless nodules but can mimic benign conditions.

Purpose of the Study:

  • To review the clinical presentation, diagnosis, and management of cutaneous metastases.
  • To highlight the importance of recognizing skin involvement as a sign of advanced malignancy.

Main Methods:

  • Review of literature on cutaneous metastases.
  • Analysis of common primary cancer types and their metastatic patterns to the skin.
  • Description of diagnostic confirmation via biopsy and histopathology.

Main Results:

  • Cutaneous metastases are uncommon but associated with poor prognosis.
  • Diverse presentations can mimic benign skin lesions, necessitating high clinical suspicion.
  • Biopsy is crucial for diagnosis and can help identify the primary tumor.

Conclusions:

  • Early recognition and accurate diagnosis of skin metastases are critical for patient management.
  • Treatment strategies are multimodal, including surgical, chemotherapeutic, immunotherapeutic, and palliative approaches.
  • Understanding the varied presentations of cutaneous metastases improves diagnostic accuracy and patient outcomes.