Management of the Small Renal Mass: a 2020 Update

Rand N Wilcox Vanden Berg1, Spyridon P Basourakos1, Samuel LaRussa2,3

  • 1Department of Urology, Weill Cornell Medicine/New York Presbyterian, New York, NY, USA.

Abstract

Insights

Small renal masses (SRMs) are increasingly detected. Biopsies aid diagnosis, and while active surveillance has risks, treatments like ablation and surgery offer similar outcomes for these low-malignancy tumors.

Area of Science:

  • Urology
  • Oncology
  • Diagnostic Imaging

Background:

  • Small renal masses (SRMs), defined as tumors ≤ cT1a (less than 4 cm), are increasingly diagnosed due to advances in cross-sectional imaging.
  • SRMs have a low potential for malignancy and metastasis, yet a significant proportion are found to be benign upon surgical removal.

Purpose of the Study:

  • To review current diagnostic and treatment strategies for small renal masses.
  • To evaluate the efficacy and outcomes of various management options for SRMs.

Main Methods:

  • Review of diagnostic tools, including renal biopsy, for characterizing SRMs.
  • Analysis of treatment modalities such as active surveillance, surgical intervention (partial nephrectomy and radical nephrectomy), and percutaneous ablation techniques.

Main Results:

  • Renal biopsy can assist in pre-treatment diagnosis, potentially avoiding unnecessary interventions.
  • Active surveillance may be linked to poorer cancer-specific survival, but interventional methods (surgery and ablation) demonstrate comparable outcomes.
  • Percutaneous ablation techniques have advanced and are now recognized in clinical guidelines.

Conclusions:

  • Accurate diagnosis of SRMs is crucial, with renal biopsy playing a key role.
  • Active surveillance, surgery, and thermal ablation are viable treatment options for SRMs, each with distinct side effect profiles but similar overall outcomes.

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