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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Endocrine vigilance in COVID-19
Fritz-Line Velayoudom1, Piyumi Sachindra Alwis Wijewickrama2, H Ishara Ranathunga2
1Department of Diabetology-Endocrinology, University Hospital of Guadeloupe , Guadeloupe.
Abstract:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus responsible for a pandemic that emerged in December 2019. Heterogeneous clinical forms are described from asymptomatic to severe hypoxaemic acute respiratory syndrome with multisystem organ failure. The impact of this coronavirus disease 2019 on the endocrine glands remains unknown. However, the results of previous studies on viruses from the same family allow us to write proposals for patients followed for chronic endocrine diseases. Currently, if these subjects are infected with SARS-CoV-2, they must not stop their treatment. In some cases, hormone replacement doses have to be increased. In case of worsening clinical signs, hormonal biological monitoring must be done. This article will be helpful for improving the management of chronic endocrine diseases that could affect thyroid, adrenals, gonads and pituitary gland functions. Proposals could be applied in COVID-19 infected subjects or in those who have been in contact with COVID-19 infected people.
Insights
Patients with chronic endocrine diseases should continue treatment if infected with SARS-CoV-2 (COVID-19). Hormone replacement doses may need adjustment, and monitoring is crucial for managing thyroid, adrenal, gonadal, and pituitary functions.
Area of Science:
- Endocrinology
- Infectious Diseases
- Virology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a pandemic with diverse clinical presentations.
- The effect of SARS-CoV-2 on endocrine glands is not fully understood.
- Previous research on related viruses suggests potential impacts on endocrine function.
Purpose of the Study:
- To provide guidance for managing patients with chronic endocrine diseases during the SARS-CoV-2 pandemic.
- To outline necessary adjustments in treatment and monitoring for endocrine disorders in the context of COVID-19.
Main Methods:
- Review of existing literature on viral impacts on endocrine systems.
- Clinical recommendations based on current understanding of SARS-CoV-2 and endocrine pathophysiology.
- Proposal of management strategies for specific endocrine glands (thyroid, adrenals, gonads, pituitary).
Main Results:
- Patients with chronic endocrine conditions should not discontinue their treatments when infected with SARS-CoV-2.
- Hormone replacement therapy doses may require upward adjustments in some cases.
- Hormonal biological monitoring is recommended in case of clinical deterioration.
Conclusions:
- This article offers practical proposals for the management of chronic endocrine diseases (thyroid, adrenal, gonadal, pituitary) in patients affected by or exposed to SARS-CoV-2.
- Adherence to treatment and vigilant monitoring are key to managing endocrine function during the COVID-19 pandemic.
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